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Farnesoid X receptor protects against kidney injury in uninephrectomized obese mice

機譯：Farnesoid X受體可保護未切除直腸的肥胖小鼠免受腎臟損傷

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Activation of the farnesoid X receptor (FXR) has indicated a therapeutic potential for this nuclear bile acid receptor in the prevention of diabetic nephropathy and obesity-induced renal damage. Here, we investigated the protective role of FXR against kidney damage induced by obesity in mice that had undergone uninephrectomy, a model resembling the clinical situation of kidney donation by obese individuals. Mice fed a high-fat diet developed the core features of metabolic syndrome, with subsequent renal lipid accumulation and renal injury, including glomerulosclerosis, interstitial fibrosis, and albuminuria. The effects were accentuated by uninephrectomy. In human renal biopsies, staining of 4-hydroxynonenal (4-HNE), glucose-regulated protein 78 (GRP78) and C/EBP-homologous protein (CHOP), markers of ER stress, was more prominent in the proximal tubules of 15 obese compared with 16 non-obese patients. In mice treated with the FXR agonist obeticholic acid (OCA), renal injury, renal lipid accumulation, apoptosis and changes in lipid peroxidation were attenuated. Moreover, disturbed mitochondrial function was ameliorated and the mitochondrial respiratory chain recovered following OCA treatment. Culturing renal proximal tubular cells with free fatty acid (FFA) and FXR agonists showed that FXR activation protected cells from FFA-induced oxidative stress and ER stress, as denoted by a reduction in the level of ROS staining and Grp78 immunostaining, respectively. Several genes involved in glutathione metabolism were induced by FXR activation in the remnant kidney, which was consistent with a decreased glutathione disulfide / glutathione ratio. In summary, FXR activation maintains endogenous glutathione homeostasis and protects the kidney in uninephrectomized mice from obesity-induced injury.

機譯：法尼醇X受體（FXR）的激活表明該核膽汁酸受體在預(yù)防糖尿病性腎病和肥胖引起的腎臟損害方面具有治療潛力。在這里，我們研究了FXR對肥胖的小鼠的腎臟保護作用，該小鼠已進行了單腎切除術(shù)，該模型類似于肥胖個體捐贈腎臟的臨床情況。飼喂高脂飲食的小鼠出現(xiàn)了代謝綜合征的核心特征，隨后出現(xiàn)了腎脂質(zhì)積聚和腎損傷，包括腎小球硬化，間質(zhì)纖維化和蛋白尿。腎切除術(shù)加重了這種作用。在人類腎臟活檢中，在15例肥胖的近端腎小管中，4-羥壬烯醛（4-HNE），葡萄糖調(diào)節(jié)蛋白78（GRP78）和C / EBP同源蛋白（CHOP）（ER應(yīng)激的標志物）的染色更為突出。與16位非肥胖患者相比。在用FXR激動劑奧貝膽酸（OCA）治療的小鼠中，腎損傷，腎脂質(zhì)蓄積，細胞凋亡和脂質(zhì)過氧化作用的改變被減弱。此外，OCA處理后，線粒體功能紊亂得到改善，線粒體呼吸鏈得以恢復(fù)。用游離脂肪酸（FFA）和FXR激動劑培養(yǎng)腎近端腎小管細胞表明，F(xiàn)XR激活可保護細胞免受FFA誘導的氧化應(yīng)激和ER應(yīng)激的影響，這分別表示為ROS染色水平降低和Grp78免疫染色降低。殘余腎臟中的FXR激活誘導了一些與谷胱甘肽代謝有關(guān)的基因，這與降低的谷胱甘肽二硫鍵/谷胱甘肽比例一致?？偠灾?，F(xiàn)XR激活可維持內(nèi)源性谷胱甘肽穩(wěn)態(tài)，并保護未切除直腸的小鼠免受肥胖引起的傷害。

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Gai, Zhibo; Gui, Ting; Hiller, Christian; Kullak-Ublick, Gerd A;
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年度 2015
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專利

1. Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice [J] . LeeJ., SeokS., YuP., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2012,第1期

機譯：肝法呢素X受體結(jié)合位點的基因組分析揭示了肥胖癥中結(jié)合的改變以及小鼠中法呢素X受體對基因的直接抑制
2. A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice [J] . Xiaoxin X. Wang, Yuhuan Luo, Dong Wang, The Journal of biological chemistry . 2017,第29期

機譯：法尼醇X受體（FXR）和G蛋白偶聯(lián)受體TGR5的雙重激動劑INT-767可以逆轉(zhuǎn)小鼠與年齡有關(guān)的腎臟疾病
3. Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation [J] . AjamiehH., FarrellG., WongH.J., Journal of gastroenterology and hepatology . 2012,第8期

機譯：阿托伐他汀通過抑制Toll樣受體4和激活內(nèi)皮一氧化氮合酶來保護肥胖小鼠免受肝臟缺血再灌注損傷
4. Transactivation of the Human 0atp8 Gene By the Farnesoid X Receptor/ Bile Acid Receptor (fxr/bar) [C] . G. A. Kullak-ublick, D. Jung Falk Symposium . 2003

機譯：法呢X受體/膽汁酸受體的人類0ATP8基因的轉(zhuǎn)發(fā)劑（FXR / BAR）
5. Identification and characterization of novel roles for the farnesoid X receptor in the adrenal gland and kidney. [D] . Lee, Hans A. 2007

機譯：法呢類X受體在腎上腺和腎臟中的新作用的鑒定和表征。
6. Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice [O] . Zhibo Gai, Ting Gui, Christian Hiller, 2016

機譯：Farnesoid X受體可預(yù)防未切除直腸的肥胖小鼠的腎臟損傷
7. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

機譯：早期心臟腔室specification291Bmp2期間海報會議2Morphogenetic mechanisms290MiR-133調(diào)控對視黃酸途徑在早期心臟具有或不具有2型糖尿病mellitus295Association循環(huán)的α2B腎上腺素受體基因插入/缺失多態(tài)性的缺失等位基因和高血壓的formationDevelopmental genetics294Association通過的miR-130調(diào)節(jié)心房分化陷波的作用：Vascular298Gamma分泌酶抑制劑阻止增殖和動脈導管未閉的遷移平滑肌細胞 - 內(nèi)源性大麻素1型受體（CNR1）與冠狀動脈疾病（CAD）的2型糖尿病mellitusCell生長，分化和干細胞的G1359A多態(tài)性的在出生后的閉合信令導管arteriosus299Mesenchymal基質(zhì)狀從誘導的多能干細胞（iPS）衍生的單元（MLC）細胞：有希望的治療選項，以促進neovascularization300Sonic刺猬促進間充質(zhì)干細胞分化為vascula ?平滑肌細胞cardiovacsular disease301Proinflammatory細胞因子分泌和在內(nèi)皮細胞中表觀遺傳學修飾處理的LPS-GinfivalisCell死亡和細胞凋亡 - Vascular304Mitophagy充當針對人血管平滑肌細胞中的保障機制凋亡誘導動脈粥樣硬化lipidsTranscriptional控制和RNA種類 - 在Vascular307MicroRNA-34a的作用利用后缺氧內(nèi)皮cells310Specific循環(huán)微RNA水平的血管injury309Long非編碼RNA景觀臨床適用的方法衰減新內(nèi)膜形成與miR-146a的抑制劑的血管calcification308Local遞送關(guān)聯(lián)與高血壓，高血糖和功能失調(diào)的HDL在急性冠狀動脈綜合征patientsCytokines和細胞炎癥 - Vascular313Phosphodiesterase5A向上調(diào)控血管內(nèi)皮促炎性條件下進行：為ω-3polyunsaturated aatty酸二十二碳六acid31一個新公開的抗炎活性4Cardiovascular風險修改與超低劑量抗細胞因子藥物在人M-CSF的巨噬細胞的類風濕arthritis315Conversion成泡沫細胞降低了其經(jīng)典M1偏振activation316Lymphocytic心肌炎具有增加斑塊炎癥和在冠狀動脈中的斑塊出血一致時，促進心肌infarction317Serum骨保護素水平的促炎性應(yīng)答通過抑制手段Heart323A新的合成肽對肥大體外 - predictsdeclined眾多患者的代謝syndromeGrowth因子和神經(jīng)激素循環(huán)內(nèi)皮 - 衍生的細胞和單核衍生的祖細胞 - 胃泌素釋放肽（GRP）對血管inflammationSignal轉(zhuǎn)導的Vascular320Effect p38的α圖激酶nfkb324Inducible成纖維細胞特異性敲除是在異丙基腎上腺素誘導的心臟hypertrophy325Regulation的小鼠模型中的心臟保護β-腎上腺素受體誘發(fā)由抑制性肌力響應(yīng)ORY G蛋白，腺苷酸環(huán)化酶同種型5,6和phosphodiesterases326Binding到RGS3和M2毒蕈堿性乙酰膽堿受體調(diào)制的刺激p190RhoGAP的翻譯后修飾，parylation和脫乙?；蠰MNA的心臟myocytes327Cardiac調(diào)節(jié)底物特異性擴張的心肌病小鼠model328Beta腎上腺素能調(diào)節(jié)所述b56delta / PP2A全酶在心肌細胞通過b56delta磷酸化絲氨酸573Nitric氧化物和活性氧 - Vascular331Oxidative應(yīng)激誘導的miR-200c的破壞SIRT1，F(xiàn)OXO1和eNOS332Antioxidant療法防止氧化應(yīng)激誘導內(nèi)皮功能障礙和提高之間的調(diào)節(jié)環(huán)路傷口Healing333Morphological和在冠狀動脈diseaseCytoskeleton紅細胞和機械傳導的生化特征 - Heart336Novel肌球蛋白的活化劑，JSH化合物，ratsExtracellular矩陣增加心肌收縮力沒有變時作用和纖維化 - 的Vascular339Ablation Toll樣受體9通過衰減增殖和心臟fibroblasts340Altered血管在因子VII小鼠后肢缺血模型重塑活化蛋白酶（FSAP）deficiencyVasculogenesis，血管生成和proly的arteriogenesis343Pro血管生成作用的分化導致心肌梗死后心臟破裂羥化酶抑制劑及其在用于冠狀動脈總occlusion344Nrf2驅(qū)動治療性血管生成的新穎的策略的使用潛在的血管生成轉(zhuǎn)錄非依賴性方式：氧化應(yīng)激response345Angiogenic基因治療的主調(diào)節(jié)器的新功能，盡管高效血管生長，不能改善上在鼠后肢側(cè)支血管生長PAR-1抑制的毛細動脈和shunting346Effect在含氧量正?；蚵匀毖院笾耐眉∪夤δ?Role model347Quaking是內(nèi)皮細胞分化的關(guān)鍵調(diào)節(jié)劑，新血管形成和angiogenesis348在雞胚絨毛尿囊膜（CAM）“新興血管生成”。一種不同于心肌祖細胞體內(nèi)study349Exosomes和間充質(zhì)干細胞刺激血管生成的體外和GRK2的體內(nèi)經(jīng)由EMMPRINEndothelium352Reciprocal調(diào)節(jié)和血管舒緩激肽受體刺激調(diào)制的Ca 2+的細胞內(nèi)骨的內(nèi)皮cells353The角色形態(tài)發(fā)生蛋白9和10在內(nèi)皮炎癥和atherosclerosis354The貢獻水平GPR55在分離的人將L-α-溶血磷脂酰肌醇誘導的血管舒張肺arteries355The內(nèi)皮保護ACE抑制劑Zofenoprilat通過H2S production356A類新的糖模擬藥物發(fā)揮抗炎活性，以防止游離脂肪酸誘導的內(nèi)皮dysfunction357Endothelial祖細胞凋亡的內(nèi)皮細胞從降低噴射fractionheart failure358Proosteogenic基因保留衍生微粒配給differentiatesas在患者的胸主動脈aneurysm359Endothelin ETB REC內(nèi)皮細胞活化通過經(jīng)由PI3Kg的對cAMP調(diào)節(jié)，在動脈的作用IP3 receptors363A新穎功能的激活誘導的鈣振蕩eptors調(diào)解放松來自患有心血管疾?。–VD）的平滑肌和pericytes362CX3CR1陽性髓樣細胞在心包阻力動脈到胰島素應(yīng)答調(diào)節(jié)血管平滑肌緊張壁增生，通過平滑肌細胞proliferation364NRP1和NRP2的調(diào)制內(nèi)膜增生的發(fā)展vivo365Azithromycin誘導自噬在主動脈平滑肌cellsCoagulation，血栓形成和platelets368The實時血小板依賴性醛固酮促血栓形成作用的體內(nèi)評價mice369Development玩的方法的重要作用用于體內(nèi)在mice370The活性血栓的檢測抗血小板的血小板聚集和腺苷的人類platelets372Regulation的功能狀態(tài)肝素抗凝藥物的牛磺酸chloramine371The影響結(jié)構(gòu)類似物的效果二磷酸酯的釋放通過d二聚體在急性冠狀動脈綜合征（體外研究）氧傳感，局部缺血和腦缺血reperfusion376Abscisic酸的小鼠模型reperfusion375Sirtuin 5介導的腦損傷：在從局部缺血心肌保護的新播放ultramicronized十六酰胺乙醇的377Protective效果（？ PEA-UM）在干細胞衍生的心肌細胞的vivo378Identification心肌缺血再灌注損傷的使用心臟特異性標志物，并在這些細胞中的額外的測試模擬缺血/再灌注system379Single劑量靜脈二甲雙胍治療能買得起在受傷大鼠腎臟的顯著保護的長效用于慢性阻塞性肺disease381Dependence抗氧化潛力上的缺血 - 再灌注的生理參數(shù)，細胞凋亡和超微結(jié)構(gòu)氨基acids382The沖擊濃度毒蕈堿性受體拮抗劑缺血reperfusion380Cardiotoxicity的實驗?zāi)Ｐ屯眯募嶒瀉terosclerosisMitochondria和energetics385MicroRNA-1在正常線粒體鈣單向轉(zhuǎn)運體（MCU）的依賴性調(diào)節(jié)和肥大hearts386Mitochondrial穩(wěn)態(tài)和心臟保護：在糖尿病heart388NO結(jié)蛋白和線粒體融合蛋白-2 AB-crystallin387Overexpression（Mfn2的）和相關(guān)的線粒體功能障礙共同目標依賴性預(yù)防通透性轉(zhuǎn)換孔（MPTP）的開口由H 2 S和其在大鼠心臟mitochondria389G蛋白偶聯(lián)受體的Ca 2+積累的調(diào)節(jié)激酶2（GRK2）是在回收曝光后線粒體形態(tài)和功能于電離輻射（IR）性別issues392Sex差異基本在肺血管的控制;注重與射血分數(shù)一氧化氮pathwayAging395Heart失敗開發(fā)當饋送西方飲食到衰老加速mice396Cardiovascular標志物的中老年大鼠與體積連接蛋白43在老年高血壓patients397Changes認知衰退的預(yù)測過載慢性心臟failureGenetics和epigenetics400Calcium內(nèi)容在主動脈瓣與1G相關(guān)聯(lián)> 2G矩陣男性高血壓并發(fā)和不復(fù)雜的與脂蛋白脂肪酶的常見多態(tài)性與PON1基因的慢性心臟failure403Association與代謝綜合征金屬蛋白酶1個polymorphism401Neuropeptide受體基因S（NPSR1）多態(tài)性與睡眠disturbances402Endothelin-1基因Lys198Asn多態(tài)性社區(qū)participantsGenomics，蛋白質(zhì)組學，代謝組樣品中使用復(fù)用顏色編碼的探針對脂質(zhì)組學和glycomics405Gene表達定量，以確定在經(jīng)受的橄欖油的新抗炎性質(zhì)基于injury407Transcriptome-缺血/再灌注鑒定2型糖尿病心臟的零星心臟myxoma406Large規(guī)模磷酸化研究RNA含量羥基酪醇在血管內(nèi)皮細胞在人類心室動作potentialMetabolism，糖尿病三個國家的最先進的車型在基礎(chǔ)和促炎conditions408Gene多態(tài)性組合和心肌infarctionComputer建模，生物信息學和復(fù)極儲備的大data411Comparison的風險細胞和單核細胞obesity414Endothelial激活多肽-II型糖尿病-I mellitus415Admission葡萄糖水平改善心臟功能的左心室功能受損患者急性心肌梗死的獨立預(yù)測因子：二維斑點追蹤超聲心動圖脂質(zhì)譜和炎癥反應(yīng)，在高血壓患者腹部obesity417Multiple常見共病血管壁的剛度的生化標志物之間ystudy416Association產(chǎn)生左心室冠狀動脈微血管功能障礙，氧化應(yīng)激和心肌stiffening418Investigating的抗逆轉(zhuǎn)錄病毒藥物的心血管作用有關(guān)的舒張功能障礙貧和高脂肪/非酒精性脂肪性肝炎（NASH）的治療obesity419Statins的蔗糖飲食大鼠模型。我們在康斯坦察縣2年的前瞻性研究經(jīng)驗，Romania420Epicardial脂肪組織心血管結(jié)果的ACS患者接受PCI？動脈及肺動脈hypertension423Dependence心臟節(jié)律disorers和ACE基因ID多態(tài)性與高血壓patients424Molecular機制背后的有益預(yù)測在TGF-β軸和在人類升主動脈中prehypertension427Vascular微循環(huán)和大循環(huán)異常aneurysms426Early跡象腎素 - 血管緊張素系統(tǒng)的動作的肺動脈hypertension425Inhibition尿皮質(zhì)素2的影響平滑肌細胞表達的血管tone428Cardiac鐵2控制和血管重塑在開發(fā)在一個新穎的豬modelBiomarkers431Arrhythmogenic心肌病慢性血栓栓塞性肺動脈高壓：一個新的，非侵入性的biomarker432Can循環(huán)微RNA區(qū)分類型1和類型2心肌梗塞433Design的高通量含多處？前蛋白質(zhì)組學測定，以確定左室舒張功能障礙diabetes434Monocyte衍生和P-選擇攜帶微粒不同由低脂肪飲食的患者心血管危險因素誰將會和誰不會被開發(fā)寬度評估心血管event435Red血細胞分布修改在慢性心臟failure436Invasive和患者的治療低溫對腦的水平心房fibrillation437The效果射頻誘導的心臟去神經(jīng)支配的質(zhì)量的非侵入性評價薄膜的多色干涉顯微鏡中的血清衍生的神經(jīng)營養(yǎng)因子（BDNF）以下心肺resustitation438Novel生物標志物來預(yù)測結(jié)果患者心臟衰竭和冠狀動脈graftingInvasive，非侵入性和分子imaging443Diet組成的影響?鏈接抑郁和焦慮心血管disease440Troponins和肌紅蛋白動態(tài)重度主動脈瓣stenosis439Biological因素n中的鼠ob突變的基因分型，：心臟功能，宏觀和微觀循環(huán)和使用IV-OCT定量分析豬冠狀動脈和兔子主動脈的病變的肝steatosis444Characterization的微超聲表征：與histologyGene療法和細胞相關(guān)性therapy447Enhancing存活和小鼠心房間充質(zhì)cells448VCAM-1在實驗性心肌梗塞表達及其與骨髓來源的單核細胞retentionTissue engineering451Advanced多層支架增加干細胞衍生的工程改造的心臟組織的人類cardiomyocytes452Response的成熟到模擬缺血/再灌注的血管生成潛力急性高血糖conditions453Serum白蛋白水凝膠的存在防止新生兒cardiomyocytes454A新穎畫筆技術(shù)的去分化為低粘度的轉(zhuǎn)印紫外光可固化青色甲基丙烯酸酯上的鹽水浸沒在體外羊心臟

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Farnesoid X receptor protects against kidney injury in uninephrectomized obese mice

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